At around 6pm Pacific today I was on Ialadris Vesparion, and doing some inventory management in Sanctuary. I suddenly received the message "Lost Item: Arachnid Mandible" â€" which was the weapon I had equipped â€" and the item vanished from my inventory. It didn't fall to the ground, it just disappeared. I was alone in the area at the time, and the ground was clear: as far as I can tell, it simply vanished.
Here's a screenshot taken almost immediately after, showing the Lost Item message:
[hide=Lost Item](http://i.imgur.com/n5vnfiH.jpg)[/hide]